Steven A. Kushner

The paper shows that SYNGAP1 splice-switching therapy may be ineffective in mature neurons due to reduced A3SS transcript abundance.

This paper introduces a method to generate adherent cortical organoids in a multiwell format, showing reproducible 3D cortical layer formation and potential for drug discovery and disease modeling.

This study shows that Influenza A Virus infection impairs neuronal activity in human iPSC-derived neural co-cultures without causing cell death or efficient virus replication.

This study demonstrates that dissociated hippocampal cells can self-organize into network dynamics similar to in vivo cognitive cell assemblies, showing resilience and response to perturbations.

This study shows that complex learning abilities can be inherited through epigenetic modifications in the mammalian brain, as offspring of trained rodents exhibit enhanced neuronal excitability and DNA methylation changes.

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

This study identifies genetic risk loci and factors underlying clinical subtypes of bipolar disorder using GWAS and meta-analysis.

This study investigates how SETD1A disruption affects gene regulation and neurodevelopment, linking it to schizophrenia risk through chromatin and transcriptomic analyses in human organoids.

This study develops a method to differentiate human pluripotent stem cells into functional astrocytes in 28 days, validated by marker expression and network activity support.

This study investigates neuronal hyperactivity in human cerebral organoids derived from individuals with grey matter heterotopia, identifying functional and structural changes linked to the condition.

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

This study investigates hyperexcitability of parvalbumin interneurons in the hippocampus of a 22q11DS mouse model and identifies Kv1.1 channel dysfunction as a contributing factor.

The paper identifies a minimum threshold for myelination of pyramidal neurons' axons in human and mouse neocortex based on axonal calibre and interbranch distance.

This study shows that juvenile demyelination impairs prefrontal cortex PV interneuron maturation and function, leading to long-term behavioral deficits, while adult demyelination has no significant effects.

This study shows that myelination of parvalbumin-positive interneurons is essential for fast inhibition and modulation of cortical oscillations during specific behavioral states.

This study investigates the long-term effects of parity on maternal brain structure using a large cohort, finding a significant association with increased global gray matter volume.

This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.

GenNet predicts phenotypes from genetic variants using interpretable deep learning, identifying genes and pathways associated with traits like hair color and schizophrenia.

This study identifies 24 genetic loci associated with facial shape variation in humans through GWAS and confirms 13 of them in a multi-ethnic cohort.

This study assesses the within-subject consistency of paired associative stimulation (PAS) using linear mixed models and finds poor consistency and significant potentiation during PAS induction.