Author

Huixiang Zhu

Columbia UniversityORCID 0009-0004-6919-0022Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Sander MarkxiD· 3 shared Steven A. KushneriD· 3 shared Francesco Gavino BrunduiD· 2 shared Joseph A. GogosiD· 2 shared Kam W. LeongiD· 2 shared Raju TomeriD· 2 shared Yan SuniD· 2 shared Zhixiong SuniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Sander MarkxORCID

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4 papers

Recent·Most cited

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

Sneha B. Rao, Zhixiong Sun, Francesco Gavino Brundu, Yannan Chen, Yan Sun, Huixiang Zhu, Robert J. Shprintzen, Raju Tomer, Raúl Rabadán, Kam W. Leong, Sander Markx, Steven A. Kushner, Bin Xu, Joseph A. Gogos

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

Nature Communications · Aug 1, 2025Peer-reviewedNeuroscience

Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease Risk

Zhixiong Sun, Huixiang Zhu, Xiaofu He, Bas Lendemeijer, Zanxu Wang, Jack Fan, Yan Sun, Zhiguo Zhang, Sander Markx, Steven A. Kushner, Bin Xu, Joseph A. Gogos

This study investigates how SETD1A disruption affects gene regulation and neurodevelopment, linking it to schizophrenia risk through chromatin and transcriptomic analyses in human organoids.

bioRxiv · Mar 26, 2025 · PreprintNeuroscience

Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids

Hye Sung Kim, Yang Xiao, Xuejing Chen, Siyu He, Jongwon Im, Moshe J. Willner, Michael O. Finlayson, Cong Xu, Huixiang Zhu, Se Joon Choi, Eugene V. Mosharov, Hae‐Won Kim, Bin Xu, Kam W. Leong

This study examines the effects of chronic and acute fentanyl exposure on midbrain organoids, finding that chronic treatment arrests neuronal development and alters synaptic pathways.

Advanced Science · Mar 28, 2024Peer-reviewedNeuroscience

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

Job O. de Jong, Ceyda Llapashtica, Matthieu Genestine, Kevin A. Strauss, Frank A. Provenzano, Yan Sun, Huixiang Zhu, Giuseppe P. Cortese, Francesco Gavino Brundu, Karlla Welch Brigatti, Barbara Corneo, Bianca Migliori, Raju Tomer, Steven A. Kushner, Christoph Kellendonk, , Sander Markx

This study uses patient-derived forebrain organoids to investigate the effects of a CNTNAP2 mutation on cortical development, finding increased cell proliferation and differential gene expression associated with ASD.

Nature Communications · Sep 1, 2021Peer-reviewedNeuroscience