Integrating Machine-learning and Ultra-high-throughput Screening for Enzyme spaces exploration
Yitao Ke, Yanzhe Zhang, Minchao Fang, Jingyang Zhao, Hao Zhu, Zehui Xu, Longxing Cao
This paper introduces IMUSE, a method combining machine learning and ultra-high-throughput screening to explore enzyme spaces, identifying mutations that significantly improve enzyme activity.
bioRxiv · Jun 24, 2026 · PreprintBiochemistry