Author

Yanzhe Zhang

Westlake UniversityORCID 0000-0002-8460-4789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Longxing CaoiD· 2 shared Minchao FangiD· 2 shared Yitao KeiD· 2 shared Chentong WangiD· 1 shared Fengbai Lian· 1 shared Hao ZhuiD· 1 shared Jingyang ZhaoiD· 1 shared Jungang ShiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Longxing CaoORCID

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2 papers

Recent·Most cited

Integrating Machine-learning and Ultra-high-throughput Screening for Enzyme spaces exploration

Yitao Ke, Yanzhe Zhang, Minchao Fang, Jingyang Zhao, Hao Zhu, Zehui Xu, Longxing Cao

This paper introduces IMUSE, a method combining machine learning and ultra-high-throughput screening to explore enzyme spaces, identifying mutations that significantly improve enzyme activity.

bioRxiv · Jun 24, 2026 · PreprintBiochemistry

HalluDesign: Protein Optimization and de novo Design via Iterative Structure Hallucination and Sequence Design

Minchao Fang, Chentong Wang, Jungang Shi, Fengbai Lian, Qihan Jin, Zhe Wang, Yanzhe Zhang, Peipei Chen, Zhanyuan Cui, Yanjun Wang, Ze Zhang, Yitao Ke, Qingzheng Han, Longxing Cao

HalluDesign optimizes and designs proteins using iterative structure hallucination and sequence design, achieving high success rates and structural accuracy in various tasks.

bioRxiv · Nov 8, 2025 · PreprintBioinformatics