A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout life
Zelah Joel, Pablo Izquierdo, Dervis A. M. Salih, Jill C. Richardson, Damian M. Cummings, Frances A. Edwards
This paper compares the effects of amyloid-beta plaques and Tau tangles in mouse models of dementia, showing that tangles cause severe neurodegeneration while plaques affect synaptic transmission and immunity earlier.
bioRxiv · Sep 19, 2018Neuroscience