Jill C. Richardson

The paper establishes a human microglial ferroptosis model using HMC3 cells and identifies dysregulated lipid species and metabolic pathways associated with ferroptosis.

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

This study identifies CDKL5 as a kinase that phosphorylates Cav2.3, altering its function and contributing to neuronal excitability in CDKL5 deficiency disorder.

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

The paper conducts a genome-wide association study (GWAS) on Alzheimer’s disease CSF biomarkers in the EMIF-AD dataset, identifying novel genetic signals and confirming existing associations.

The paper quantifies changes in dynamic functional connectivity (dFC) speed after sleep deprivation and finds that modular dFC speed correlates with task-specific cognitive performance declines.

This study examines how rising amyloidβ levels affect synaptic transmission, microglial response, and cognition in APPSwe/PSEN1M146V transgenic mice before and after plaque formation.

This paper compares the effects of amyloid-beta plaques and Tau tangles in mouse models of dementia, showing that tangles cause severe neurodegeneration while plaques affect synaptic transmission and immunity earlier.

The paper combines GWAS, clinical data, and experimental models to identify JAK-STAT pathway dysregulation as a potential therapeutic target for Alzheimer’s disease.