Pablo Izquierdo

This paper describes a pilot study in Spain that used visual communications to reduce the environmental footprint of laboratory research, showing increased engagement with sustainability practices across multiple metrics.

This study examines how amyloidosis and ageing differentially affect microglial calcium activity in mouse brains, revealing distinct patterns in somatic and process Ca2+ responses.

This study shows that THIK-1 K+ channels in microglia regulate phagocytosis and synaptic pruning, with loss of THIK-1 increasing synaptic density in the hippocampus.

This study develops a fluorescent Aβ analogue to monitor glial cell phagocytosis of amyloid β in real time, showing microglia uptake exceeds astrocytes.

This study shows that amyloid β oligomers constrict human capillaries via pericyte signaling, reducing blood flow and contributing to Alzheimer’s disease pathology.

This paper compares the effects of amyloid-beta plaques and Tau tangles in mouse models of dementia, showing that tangles cause severe neurodegeneration while plaques affect synaptic transmission and immunity earlier.