CRISPR-based targeted haplotype-resolved assemblies of a megabase region
Taotao Li, Duo Du, Dandan Zhang, Yicheng Lin, Jiakang Ma, Mengyu Zhou, Weida Meng, Zelin Jin, Ziqiang Chen, Haozhe Yuan, Jue Wang, Shulong Dong, Shaoyang Sun, Wenjing Ye, Bosen Li, , Yun Liu
This paper demonstrates a CRISPR-based method to construct haplotype-resolved assemblies of targeted genomic regions, achieving comparable accuracy with reduced cost and complexity.
Nature Communications · Jan 3, 2023Peer-reviewedGenomics