Yun Liu

This study identifies IL-21-producing Tph cells in tertiary lymphoid structures of biliary atresia patients and shows IL-21R blockade reduces disease severity in a mouse model.

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

This paper establishes a syngeneic immunocompetent mouse model of gallbladder cancer that recapitulates human disease features and therapeutic responses.

The paper identifies and analyzes nonreference sequences in human genomes using long-read sequencing and graph-based pangenome methods, revealing their functional, evolutionary, and phenotypic significance.

This paper demonstrates a CRISPR-based method to construct haplotype-resolved assemblies of targeted genomic regions, achieving comparable accuracy with reduced cost and complexity.

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.