Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X
Adele Mossa, Lauren Dierdorff, Jerónimo Lukin, Marta García-Forn, Wei Wang, Fatemeh Mamashli, Yeaji Park, Chiara Fiorenzani, Zeynep Akpinar, Janine Kamps, Jörg Tatzelt, Zhuhao Wu, Silvia De Rubeis
This study shows that Ddx3x mutations cause sex-specific changes in neuronal development and behavior, affecting ribosomal biogenesis, dendritic growth, and motor function in mice.
Nature Communications · May 15, 2025Peer-reviewedNeuroscience