Zhuhao Wu

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

This study benchmarks AlphaFold3's antibody-antigen binding predictions using experimental data and identifies biases and false positives in its performance.

This study shows that Ddx3x mutations cause sex-specific changes in neuronal development and behavior, affecting ribosomal biogenesis, dendritic growth, and motor function in mice.

This study shows that remote ischemic conditioning (RIC) improves stroke recovery by altering monocyte composition and CD36-mediated efferocytosis in macrophages, which reduces transneuronal degeneration.

This study shows human glioblastoma cells integrate into brain-wide neuronal circuits, exhibit diverse connectivity, and respond to neuromodulatory inputs like acetylcholine, which promotes invasion and survival.

The paper maps cell type densities in the mouse brain using single-cell imaging and computational analysis, revealing sex differences, shared signatures among brain regions, and associations between cell densities and anatomical functions.

This study develops a high-throughput in vivo Perturb-seq platform to analyze gene function across diverse cell types in the brain and peripheral nervous system, identifying cell type-specific transcriptional networks.

The R136S mutation on APOE3 enhances resistance to tau-related pathology and toxicity by downregulating the cGAS-STING-IFN signaling pathway.

This paper improves axon segmentation in light-sheet microscopy images by fine-tuning the TrailMap model with expert-labeled data, achieving better recall and adjusted F1-score.

This study uses interspecies neural blastocyst complementation to build and test functional rat-mouse neural circuits in rat-mouse brains, showing synaptic activity and partial behavioral rescue.

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.

The paper profiles vascular and perivascular cells in different brain regions to reveal molecular and cellular bases of blood-brain barrier heterogeneity.

The paper introduces an optimized tissue clearing protocol for rat brains and develops an open-source platform for high-throughput analysis.

The paper introduces LS-SOFI, a method combining light-sheet fluorescence microscopy and super-resolution optical fluctuation imaging for fast nanoscale-resolution imaging in 3D tissues.

The paper shows that reduction of cerebellar nuclei neurons leads to proportional scaling down of cerebellar cortex growth due to loss of their presynaptic Purkinje cells.

The paper reconstructs 1,000 projection neurons in the mouse brain, revealing new cell types and organizational principles of long-range connectivity.