Jörg Tatzelt

This study shows that Ddx3x mutations cause sex-specific changes in neuronal development and behavior, affecting ribosomal biogenesis, dendritic growth, and motor function in mice.

This study shows that membrane anchors prevent protein misfolding and aggregation by restricting conformational freedom, with implications for prion diseases.

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.