Regulation of alternative polyadenylation isoforms of Timp2 is an effector event of RAS signaling in cell transformation
Yuxi Ai, Qingbao Ding, Zezhong Wan, Sanjay Tyagi, Alexandra Indeglia, Maureen E. Murphy, Bin Tian
This study shows that RAS signaling regulates Timp2 alternative polyadenylation isoforms, with the long 3UTR isoform enhancing secreted protein expression and contributing to cell transformation.
bioRxiv · Sep 26, 2024 · PreprintMolecular Biology