Yuxi Ai

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

This paper identifies a U1-U3 snRNA-snoRNA interaction that links SF3B1 mutations to chromatin-state changes and genome instability, with therapeutic potential through antisense oligonucleotides.

This study shows that RAS signaling regulates Timp2 alternative polyadenylation isoforms, with the long 3UTR isoform enhancing secreted protein expression and contributing to cell transformation.

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

The paper compares off-target effects of CRISPR/Cas13 effectors in eukaryotic cells, finding significant variability in specificity across different effectors and cell types.