Bin Tian

This study shows that inhibiting CPSF73, an mRNA 3' end processing enzyme, reduces cancer cell proliferation and reverses the mesenchymal state by altering alternative polyadenylation (APA) patterns and 3'UTR lengths in multiple cancer cell lines.

The paper compares mitochondrial genomes of Rafflesiaceae parasites and their host to show how horizontal gene transfer and structural changes lead to divergent mitogenome architectures.

This study uses single-cell lineage tracing to map clonal and transcriptional dynamics in melanoma metastasis, identifying distinct transcriptional programs and spatial organization patterns.

This study shows that RAS signaling regulates Timp2 alternative polyadenylation isoforms, with the long 3UTR isoform enhancing secreted protein expression and contributing to cell transformation.

This study shows that CFIm25 promotes macrophage differentiation by enhancing alternative polyadenylation and activating the NF-κB pathway.

The paper investigates how light regulates alternative polyadenylation (APA) in Arabidopsis thaliana, finding that light affects APA in 30% of genes and involves chloroplasts and mitochondrial activity.

The paper identifies ZFC3H1 and U1-70K as factors promoting nuclear retention of mRNAs with 5' splice site motifs in nuclear speckles through a splicing-independent mechanism.

SCAPTURE identifies and quantifies cleavage and polyadenylation sites from 3' tag-based scRNA-seq, improving cell identity refinement.

MAAPER analyzes alternative polyadenylation using nearSite reads, accurately predicting PASs and examining APA events with robust statistics across bulk and single-cell RNA samples.

The paper identifies serotype-specific genetic loci in R. anatipestifer using Pan-GWAS and develops a multiplex PCR method for serotyping.

CRISPRpas regulates alternative polyadenylation by dCas9, altering PAS usage and demonstrating its impact on gene expression and APA-related SNPs.

The paper identifies a U1 snRNP recognition motif that regulates chromatin retention of noncoding RNAs through experimental and computational methods.

The paper identifies PCF11 as a critical regulator of alternative polyadenylation in neuroblastoma, linking it to cell fate reprogramming and spontaneous tumor regression.