Male-Biased Cyp17a2 Orchestrates Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation
Long-Feng Lu, Bao-Jie Cui, Sheng-Chi Shi, Yangyang Wang, Can Zhang, Xiao Xu, Meng-Ze Tian, Zhen-Qi Li, Na Xu, Zhuo-Cong Li, Dandan Chen, Li Zhou, Gang Zhai, Zhan Yin, Shun Li
This study identifies cyp17a2 as a male-biased gene that enhances antiviral immunity in zebrafish by stabilizing STING and degrading viral proteins.
bioRxiv · Jun 23, 2025Immunology