Plasma proteomics reveal heterogeneous subtypes of depression linked to inflammation and aging
Zhengxu Lian, Lena K. Palaniyappan, Yuanli Guo, Zhaowen Liu, Nanyu Kuang, Yu Liu, Yuchao Jiang, Barbara Jacquelyn Sahakian, Trevor William Robbins, Jianfeng Feng, Benjamin Becker, Wei Cheng, Xinran Wu, Edward Thomas Bullmore, Jie Zhang
The paper identifies three depression subtypes using plasma proteomics, linked to inflammation, aging, and metabolic factors, with distinct clinical and neurobiological features.
bioRxiv · May 8, 2026 · PreprintNeuroscience