Barbara Jacquelyn Sahakian

Plasma proteomics reveal heterogeneous subtypes of depression linked to inflammation and aging

The paper identifies three depression subtypes using plasma proteomics, linked to inflammation, aging, and metabolic factors, with distinct clinical and neurobiological features.

Neural correlates of device-based sleep characteristics in adolescents

The paper identifies sleep-brain dimensions and biotypes in adolescents using device-based sleep data and imaging, linking them to cognitive and academic outcomes.

Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry

The paper introduces Brain-DiT, a deep generative model for analyzing task-fMRI data, identifying cognitive regions and subgroups linked to psychiatric conditions like depression and alcohol abuse.

Information Shielding Through Neural Deactivation: A Fundamental Mechanism of Human Information Processing

The paper demonstrates that information shielding involves deactivation of neural regions, challenging the traditional view that activation is the primary mode of information processing.

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

Oxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame

This study shows oxytocin, but not vasopressin, reduces willingness to harm others by increasing guilt and shame for intentional harm.

Common roles for serotonin in rats and humans for computations underlying flexible decision-making

This study shows that serotonin manipulations affect decision-making flexibility in rats and humans through similar computational mechanisms.

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

The paper identifies harmonic patterns of structure-function dependence in the human connectome that correlate with different states of consciousness.

Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

This study shows that serotonin depletion impairs reversal learning and emotional updating in humans, correlating with the degree of tryptophan depletion.

Brain Laterality Dynamics Support Human Cognition

The paper maps dynamic brain lateralization patterns using resting-state fMRI data, revealing associations with cognitive functions and heritability.

Perseverative behavior under uncertainty is enhanced by tryptophan depletion but diminished with subclinical obsessive-compulsive symptoms

The paper was withdrawn due to substantial changes in results and interpretation after further analysis.

Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

The paper shows that serotonin depletion enhances emotional responses to social conflict, interacting with personality traits to produce distinct emotions like guilt and annoyance.

Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

This study examines how tryptophan depletion affects conditioned threat memory and finds that serotonin reduction attenuates emotional memory expression, particularly in individuals with higher intolerance of uncertainty.

Dynamic brain network changes in resting-state reflect neuroplasticity: molecular and cognitive evidence

The paper identifies genes associated with dynamic brain network changes and links them to neuroplasticity processes, showing that temporal variability predicts cognitive outcomes.

Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder

This study investigates dopaminergic modulation of prediction error responses in OCD using fMRI and computational modeling, finding bidirectional remediation of exaggerated cingulate signaling with dopamine agonists and antagonists.