Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase modulators
Meseret T. Haile, Anurag Shukla, James Zhen, Michael W. Mather, Suyash Bhatnagar, Zhening Zhang, Akhil B. Vaidya, Chi-Min Ho
The paper determines the cryoEM structure of PfATP4, revealing a novel apicomplexan-specific binding partner, PfABP, which may guide the design of new inhibitors.
bioRxiv · Feb 25, 2025 · PreprintMicrobiology