Michael W. Mather

This study identifies PF3D7_0707400 as an essential ATAD3A ortholog in Plasmodium falciparum, showing its role in mitochondrial processes and parasite survival.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This study shows that Complex III in Plasmodium falciparum has dual roles in mitochondrial protein processing and ubiquinone regeneration, even when electron transport is bypassed.

The paper determines the cryoEM structure of PfATP4, revealing a novel apicomplexan-specific binding partner, PfABP, which may guide the design of new inhibitors.

The paper models PfATP4 structure using homology and validates predictions through genetic manipulation, identifying key residues for function and resistance.