Spatial transcriptomics elucidates the central role of cerebral vasculatures in the progression of Japanese encephalitis
Zhihua Ou, Zhaoyang Wang, Qi Chen, Peidi Ren, Xiuju He, Yan Liang, Yingan Liang, Jiaxuan Wang, Sha Liao, Dexin Wang, Jie Zhao, Oujia Zhang, Zhenyu Peng, Jianxin Su, Wangsheng Li, , Gong Cheng
This study uses spatial transcriptomics to show that cerebral vasculatures, particularly meninges, drive inflammation and tissue damage in Japanese encephalitis by forming a feedback loop involving immune cells and cell death mechanisms.
bioRxiv · Mar 6, 2025 · PreprintImmunology