Xiuju He

Hypobaric hypoxia drives citrate cycle reprogramming to suppress tumor progression

This study shows hypobaric hypoxia suppresses tumor progression by reprogramming the citrate cycle and inhibiting the HIF-1 pathway, enhancing antitumor immune response and improving therapy outcomes.

Spatial transcriptomics elucidates the central role of cerebral vasculatures in the progression of Japanese encephalitis

This study uses spatial transcriptomics to show that cerebral vasculatures, particularly meninges, drive inflammation and tissue damage in Japanese encephalitis by forming a feedback loop involving immune cells and cell death mechanisms.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.