Qi Chen

Discovery and Engineering of a New BvCas12a Nuclease for Mammalian Genome Editing and Nucleic Acid Detection

The paper identifies a novel Cas12a variant, BvCas12a, with high specificity and engineers variants with broader PAM compatibility and improved editing efficiency.

Spatial transcriptomics elucidates the central role of cerebral vasculatures in the progression of Japanese encephalitis

This study uses spatial transcriptomics to show that cerebral vasculatures, particularly meninges, drive inflammation and tissue damage in Japanese encephalitis by forming a feedback loop involving immune cells and cell death mechanisms.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Heterogeneous T cell responses across Hepatitis B virus clinical phases revealed by rapid whole-blood HBV T cell analysis

This study introduces HBV-CRA, a rapid whole-blood assay that identifies immune profiles associated with HBsAg clearance and reveals heterogeneous T cell responses in chronic hepatitis B patients.