Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation
Yun Yang, Xiaojuan Fan, Yanwen Ye, Zhenzhen Zhang, Chuyun Chen, Sebastian E. J. Ludwig, Sirui Zhang, Qianyun Lu, Cindy L. Will, Henning Urlaub, Jing Sun, Reinhard Lührmann, Zefeng Wang
The paper identifies 3'UTR sequences that promote cap-independent translation initiation in human mRNAs, revealing a new regulatory mechanism involving translation factors.
Nature Communications · Aug 3, 2026Peer-reviewedMolecular Biology