Sirui Zhang

Systemic control and inter-organ communication of ovarian aging

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

Unbiased screen of human transcriptome reveals an unexpected role of 3'UTRs in translation initiation

The paper identifies 3'UTR sequences that promote cap-independent translation initiation in human mRNAs, revealing a new regulatory mechanism involving translation factors.

Causally measuring aging and rejuvenation through transcriptomic damage

This paper introduces a computational framework to quantify transcriptomic damage across tissues and conditions, revealing age-associated increases and demonstrating that interventions can alter tDamAge.

Mammalian aging involves genome-wide splicing degeneration leading to functional decline

This study identifies splicing degeneration as a hallmark of aging, showing it increases with age and is reversible with calorie restriction or rapamycin.

Nature of epigenetic aging from a single-cell perspective

The paper investigates epigenetic aging by comparing single-cell DNA methylation changes across aging and development, revealing stochastic patterns and introducing a new algorithm for analyzing CpG clusters.

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

This study uses multi-omics analysis to show that chemical reprogramming reduces biological age in mouse fibroblasts by altering metabolism and mitochondrial function.