Zefeng Wang

The paper identifies 3'UTR sequences that promote cap-independent translation initiation in human mRNAs, revealing a new regulatory mechanism involving translation factors.

This study develops a circRNA-based uricase replacement therapy that reduces serum urate levels and maintains efficacy for up to 10 weeks in uricase-knockout mice.

The paper develops a deep learning method to map SNV effects on translation efficiency, finding that variants influence disease risk through translation regulation.

HydraRNA is a full-length RNA language model that outperforms existing models in RNA-related tasks by using a hybrid architecture and diverse RNA data.

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.

This study analyzes transcriptomes across 35 human tissues to show sex-dimorphic aging patterns and their links to Alzheimer's disease and hormone levels.

This paper develops artificial RNA endonucleases (ARCs) that specifically degrade toxic RNA expansions in DM1, showing efficacy in cells and mouse models with low immunogenicity and off-target effects.

The paper develops a deep learning model to predict translation initiation and termination sites from RNA sequences, revealing new insights into translation control and identifying novel open reading frames.

The paper systematically screens RNA binding proteins that enhance circular RNA translation and identifies 68 activators, using a machine learning algorithm to predict additional candidates.

The paper introduces LAMAR, a transformer-based foundation language model for RNA regulation, which outperforms state-of-the-art methods in predicting mRNA translation efficiency and half-life.

This study identifies IRES-like elements that drive circRNA translation and shows that many endogenous circRNAs are translated into peptides.

The paper systematically identifies PRMT interactomes and shows arginine methylation regulates RNA splicing and translation by affecting ribosome assembly and cell growth.