BiochemistrybioRxivPreprint
Harnessing P450 enzyme plasticity for generalizable peptide biaryl macrocyclization
Runze Liu, Cuiping Pang, Gengfan Wu…·Yong‐Xin Li
This paper identifies a versatile P450 enzyme, GpeC, capable of catalyzing peptide biaryl macrocyclization across diverse substrates and demonstrates its application in synthesizing natural products.
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