Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights
J ZHANG, Lian Wu, Siqi Wu, Xiao Liu, Lina Dong, Eliott S. Wenger, Ridao Chen, Carsten Krebs, Alexey Silakov, Amie K. Boal, Joseph Martin Bollinger Jr., Jiahai Zhou, Binju Wang
This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.
bioRxiv · Jun 3, 2026 · PreprintBiochemistry