Harnessing P450 enzyme plasticity for generalizable peptide biaryl macrocyclization
Runze Liu, Cuiping Pang, Gengfan Wu, Bei‐Bei He, Bo Huang, Hong‐Yu Ren, Zhuanglin Shen, Jing Liu, Zhi-Man Song, Jiahai Zhou, Yong‐Xin Li
This paper identifies a versatile P450 enzyme, GpeC, capable of catalyzing peptide biaryl macrocyclization across diverse substrates and demonstrates its application in synthesizing natural products.
bioRxiv · Oct 6, 2024 · PreprintBiochemistry