Activation-induced cytidine deaminase-based in vivo continuous evolution system enables rapid protein engineering
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Deming Rao, Xiaoqian Chen, Zhigang Li, Yan Huang, Jing Wu
This paper introduces PEACE, an in vivo continuous evolution system using AID-T7 PNAP to enable rapid protein engineering by coupling gene polymorphism with toxin-antitoxin growth control.
bioRxiv · Jan 17, 2023 · PreprintMolecular Biology