Author

Sergey A. Krupenko

University of North Carolina at Chapel HillORCID 0000-0002-6926-2776Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Blake R. RushingiD· 2 shared Susan SumneriD· 2 shared Albert S. BaldwiniD· 1 shared Alexander Gevelinger Bastian· 1 shared Amanda B. Parris· 1 shared Amy G. ReynoldsiD· 1 shared Andrew S. KennedyiD· 1 shared Anna EbacheriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersImmunology

Blake R. RushingORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

Matthew P. Zimmerman, Vasyl Zhabotynsky, Haiyang Wang, Emily K. Cox, Wan Lin Chong, Alexander Gevelinger Bastian, Andrew S. Kennedy, Brian P Fay, Amy G. Reynolds, Anna Ebacher, Jeremy A. Meier, Katherine J. Vietor, Khalilah E. Taylor, Pristine C. Onuoha, Siddharth Maruvada, , Brian C. Miller

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

bioRxiv · Oct 2, 2026 · PreprintImmunology

ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells

Ming Zhao, Blake R. Rushing, Zhikun Ma, Rachel Coble, Amanda B. Parris, Tationa Campbell, Sergey A. Krupenko, Susan Sumner, Xiaohe Yang

This study shows that ALDH2 knockout in SKBR-3 cells increases cellular stress and alters arginine biosynthesis and metabolism pathways.

bioRxiv · Sep 22, 2026 · PreprintCell Biology