Author

Zhonghan Chen

Wuhan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bin ZhuiD· 1 shared Bingbing Yu· 1 shared Haoyu WangiD· 1 shared Longfei WangiD· 1 shared Shu MengiD· 1 shared Shuaihua ZhangiD· 1 shared Si Ai· 1 shared Xiang LiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Bin ZhuORCID

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1 paper

Recent·Most cited

Cleavage of the catalytic intermediate fine-tunes cGAS signalling

Yan Yan, Xiang Li, Shuaihua Zhang, Xinyuan Zhao, Bingbing Yu, Xinwei Wang, Si Ai, Zhonghan Chen, Haoyu Wang, Shu Meng, Longfei Wang, Bin Zhu

The paper identifies a regulatory mechanism that tunes cGAS signaling by cleaving a catalytic intermediate, preventing excessive activation while preserving immune function.

bioRxiv · Mar 4, 2025 · PreprintImmunology