Mitochondrial DNA Release and Activation of the cGAS-STING Pathway in Lethal Stx12 Knockout Mice
Dan-Hua Liu, Fang Li, Run‐Zhou Yang, Zhuanbin Wu, Xiao‐Yan Meng, Sen‐Miao Li, Wenxiu Li, Jian‐Sheng Kang, Dian‐Dian Wang, Ruiyu Wang, Shuang Li, Pei-Pei Liu
This study shows that STX12 deficiency leads to mitochondrial dysfunction, mtDNA release, and activation of the cGAS-STING and Type I interferon pathways in mice, contributing to lethal inflammation.
bioRxiv · Oct 7, 2024 · PreprintMolecular Biology