Engineering age-adaptive mRNA lipid nanoparticle cancer vaccines via reprogramming systemic gene expression
Yining Zhu, Christine Y. Wei, Jingyao Ma, Di Yu, Jialiang Wang, Xiaoya Lu, Kailei D. Goodier, Jinghan Lin, Xiang Liu, Yunhe Su, Zhuoqing Jiang, Autumn H. Greco, Leonardo Cheng, Wu Han Toh, Yang Miao, , Hai‐Quan Mao
This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.
bioRxiv · Apr 12, 2026 · PreprintBioengineering