Di Yu

This paper introduces NanoSTAMP, a spatially resolved in vivo screening platform for barcoded LNPs, linking formulation to cell-type uptake and tissue responses.

FALCON optimizes lipid nanoparticles for cell-selective mRNA delivery, improving transfection efficiency and selectivity in vivo.

This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.

This study shows that low-dose IL-2 therapy reverses postmenopausal bone loss by modulating immune cells and osteoclast activity in mice.

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.

This paper introduces HyperG-VAE, a Bayesian deep generative model for GRN inference using scRNA-seq data, showing effectiveness in clustering, visualization, and revealing gene regulation patterns.

This study compares dimensionality reduction methods for bulk transcriptomic data, finding UMAP better preserves sample neighbourhood and clustering accuracy than PCA, MDS, and t-SNE.