Author
Johns Hopkins UniversityORCID 0000-0002-9214-8533Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Wu Han Toh, Leonardo Cheng, Brandon Chang, Di Yu, Jingyao Ma, Xiuchun Huang, Gene Weng, Yining Zhu, Xiaoya Lu, Jinghan Lin, Jin Liu, Joseph Choy, Autumn H. Greco, Manav Jain, Joanna Yang, , Hai‐Quan Mao
FALCON optimizes lipid nanoparticles for cell-selective mRNA delivery, improving transfection efficiency and selectivity in vivo.
bioRxiv · Jun 17, 2026 · PreprintBioengineering
Yining Zhu, Christine Y. Wei, Jingyao Ma, Di Yu, Jialiang Wang, Xiaoya Lu, Kailei D. Goodier, Jinghan Lin, Xiang Liu, Yunhe Su, Zhuoqing Jiang, Autumn H. Greco, Leonardo Cheng, Wu Han Toh, Yang Miao, , Hai‐Quan Mao
This paper identifies age-related impairment in systemic mRNA translation as a barrier to mRNA vaccine efficacy and develops an LNP formulation to restore transgene expression and T cell immunity in aged hosts.
bioRxiv · Apr 12, 2026 · PreprintBioengineering
Xiang Liu, Yining Zhu, Christine Y. Wei, Jinghan Lin, Di Yu, Jiayuan Kong, Fangchi Shao, Jingyao Ma, T. Xu, Xiaoya Lu, Yunhe Su, Kailei D. Goodier, Leonardo Cheng, Wu Han Toh, Christopher J. Erb, , Hai‐Quan Mao
This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.
Nature Chemical Engineering · Feb 16, 2026Peer-reviewedBioengineering
Jinghan Lin, Yizong Hu, Turash Haque Pial, Kailei D. Goodier, Di Yu, Marine Guise, Paetra Brailsford, Maria Choi-Ali, Sixuan Li, Yining Zhu, Jingyao Ma, Leonardo Cheng, Xiaoya Lu, Nicole Korinetz, Jeff Wang, , Hai‐Quan Mao
This paper develops a method to create high-concentration, shelf-stable DNA transfection particles for AAV production, achieving tenfold higher pDNA concentration and reduced dosing volume.
bioRxiv · Jul 2, 2025 · PreprintBiochemistry
Yining Zhu, Zhi‐Cheng Yao, S.-H. Li, Jingyao Ma, Christine Y. Wei, Di Yu, Jessica L. Stelzel, Bobby Y.X. Ni, Yang Miao, Kyra Van Batavia, Xiaoya Lu, Jinghan Lin, Yifan Dai, Jiayuan Kong, Ruochen Shen, , Hai‐Quan Mao
The paper develops a nanofiber-hydrogel composite incorporating mRNA lipid nanoparticles to create a local immunostimulatory niche for cancer immunotherapy, showing enhanced immune responses with a single dose.
bioRxiv · Jan 27, 2025 · PreprintBioengineering