Molecular BiologybioRxivPreprint
Enhanced Target Binding by Leritrelvir Restores Dimerization of Mpro Mutants and Mitigates Drug Resistance
Xiaodong Huang, Petr Kuzmič, S Zhang…·Xiaoli Xiong
This study evaluates leritrelvir's effectiveness against Mpro variants with resistance mutations, showing it restores dimerization and maintains inhibitory activity better than nirmatrelvir.
DOI 10.64898/2026.06.09.730104