Author

Chuanying Niu

University of Science and Technology of China

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

Xiaoli XiongiD· 4 shared Banghui LiuiD· 3 shared Hang YuaniD· 3 shared Xinwen CheniD· 3 shared Binqian Zou· 2 shared Fandi WuiD· 2 shared Huiran Zheng· 2 shared Jianhua YaoiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Xiaoli XiongORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhanced Target Binding by Leritrelvir Restores Dimerization of Mpro Mutants and Mitigates Drug Resistance

Xiaodong Huang, Petr Kuzmič, S Zhang, Carlos A. Ramos‐Guzmán, Xiaoxin Chen, Jiacheng Gui, Qi Li, Shujuan Yan, Binqian Zou, Chuanying Niu, Y ZHAO, Haopeng Lin, Nannan Wang, Jiaheng Chen, Xinwen Chen, , Xiaoli Xiong

This study evaluates leritrelvir's effectiveness against Mpro variants with resistance mutations, showing it restores dimerization and maintains inhibitory activity better than nirmatrelvir.

bioRxiv · Jun 10, 2026 · PreprintMolecular Biology

Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to Rhinolophus cornutus Bat ACE2 and Constraints on Switching to Human ACE2

Jingjing Wang, Zexuan Li, Yong Li Jiang, Zimu Li, Hang Yuan, Chuanying Niu, Yifeng Teng, Banghui Liu, Mei Li, Min Zhou, Wenxiu Liu, Huimin Feng, Jing Chen, Jun He, Xinwen Chen, Xiaoli Xiong

This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.

PLoS Pathogens · May 21, 2026Peer-reviewedMicrobiology

Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escape

Chuanying Niu, Xiaohan Huang, Qihong Yan, Banghui Liu, Xijie Gao, Yidong Song, J. Y. Wang, Longyu Wang, Zimu Li, Huiran Zheng, Ping He, Xiaodong Huang, Hang Yuan, Binqian Zou, Yuedong Yang, , Xiaoli Xiong

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

bioRxiv · Mar 23, 2026 · PreprintImmunology

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies

Qihong Yan, Xiaohan Huang, Banghui Liu, Yicheng Yao, Huiran Zheng, Yidong Song, Fandi Wu, Zhiyun He, Shaowei Li, Fangli Chen, Chuanying Niu, Zimu Li, Hang Yuan, Yuting Lin, Lan Chen, , Jincun Zhao

The paper uses AI to identify convergent somatic hypermutation patterns in antibodies, enabling the discovery of variant-resilient broadly neutralizing antibodies from early-pandemic data.

bioRxiv · Dec 12, 2025 · PreprintImmunology