Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress
Ziyin Wu, Yingxue Fu, Yinfeng Yang, Chao Huang, Chunli Zheng, Zihu Guo, Zihao Yang, Xuetong Chen, Jinglin Zhu, Jinghui Wang, Xiaogang Li, Liyang Chen, Weiwei Zhou, Yangyang Chen, Jiangmei Wang, , Yonghua Wang
This study shows that methylglyoxal (MGO) enhances resilience to chronic stress and alleviates depression-like symptoms by promoting synaptic plasticity through TrkB activation and BDNF expression.
bioRxiv · Nov 12, 2018 · PreprintNeuroscience