Author

Xuetong Chen

Northwest A&F UniversityORCID 0000-0002-0566-0740Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Chao HuangiD· 2 shared Chunli ZhengiD· 2 shared Wei XiaoiD· 2 shared Yingxue FuiD· 2 shared Zhenzhong WangiD· 2 shared Zihu GuoiD· 2 shared Ziyin WuiD· 2 shared Aiping LüiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Chao HuangORCID

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2 papers

Recent·Most cited

NOGEA: Network-Oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning

Zihu Guo, Yingxue Fu, Chao Huang, Chunli Zheng, Ziyin Wu, Xuetong Chen, Shuo Gao, Yaohua Ma, Mohamed Shahen, Yan Li, Pengfei Tu, Jingbo Zhu, Zhenzhong Wang, Wei Xiao, Yonghua Wang

NOGEA identifies master genes driving disease initiation and comorbidity, predicts drug-disease associations, and validates new drug candidates for pancreatic cancer.

Genomics Proteomics & Bioinformatics · Mar 17, 2021Peer-reviewedSystems Biology

Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress

Ziyin Wu, Yingxue Fu, Yinfeng Yang, Chao Huang, Chunli Zheng, Zihu Guo, Zihao Yang, Xuetong Chen, Jinglin Zhu, Jinghui Wang, Xiaogang Li, Liyang Chen, Weiwei Zhou, Yangyang Chen, Jiangmei Wang, , Yonghua Wang

This study shows that methylglyoxal (MGO) enhances resilience to chronic stress and alleviates depression-like symptoms by promoting synaptic plasticity through TrkB activation and BDNF expression.

bioRxiv · Nov 12, 2018 · PreprintNeuroscience