Multi-Objective Bayesian Optimization for Data-Efficient Bioprocess Development
Edward Ma, James Morrissey, Shutong Duan, Ziqi Lu, Sandeep A. Ranpura, Sneha Arora, Anita Dabek, Chen Liu, Alexandra-Gabriela Gheorghe, Louis K. W. Fong, Maria Sani, Pavle Vrljicak, Deniz Demirhan, Michael J. Betenbaugh
This paper develops a multi-objective Bayesian Optimization framework for optimizing bioprocess conditions in CHO cell culture, achieving better performance than traditional methods with fewer experiments.
bioRxiv · Feb 4, 2026 · PreprintBioengineering