Pavle Vrljicak

Multi-Objective Bayesian Optimization for Data-Efficient Bioprocess Development

This paper develops a multi-objective Bayesian Optimization framework for optimizing bioprocess conditions in CHO cell culture, achieving better performance than traditional methods with fewer experiments.

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage

The frequency of menstrual cycles with a suboptimal decidual reaction determines the recurrence risk of miscarriage.

Spatial targeting of the prostaglandin receptor EP2 to very early endosomes co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium

The paper shows that PGE2's spatial targeting to very early endosomes is crucial for coordinating cAMP signaling in decidualizing human endometrium.

Dynamic chromatin remodeling in cycling human endometrium at single cell level

The paper uses single cell ATAC-seq to study chromatin remodeling in human endometrium across the menstrual cycle, identifying dynamic chromatin regions and their role in implantation.

Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window

The paper links a pro-senescent decidual response during the peri-implantation window to recurrent pregnancy loss, showing that immune surveillance failure leads to progesterone-resistant cells and increased miscarriage risk.