3' to 5' Translation of Circular RNAs?
Zhe Lin, Xiangyou Pi, Ziwei Lv, Tianliang Liu, Huajun Yin, Danni Shi, Muxi Li, Juan Du, Yanchao Yang, Shiyu Wang, Peng Wang, Yangmei Qin, Wenbo Lin, Tao Tao, Ling Yu Sun, , Zhi‐Liang Ji
The paper presents evidence that eukaryotic circular RNAs can be translated in the 3' to 5' direction, producing novel proteins with distinct features, and identifies millions of potential BT proteins across species.
bioRxiv · Dec 9, 2025 · PreprintMolecular Biology