Tianliang Liu

This study shows linear mRNAs can undergo backward translation in vitro, producing signals comparable to forward translation, and demonstrates the potential of backward translation in synthetic biology.

The paper presents evidence that eukaryotic circular RNAs can be translated in the 3' to 5' direction, producing novel proteins with distinct features, and identifies millions of potential BT proteins across species.

ECCFP is a bioinformatic pipeline for detecting eccDNA from long-read sequencing data, showing reduced false positives and higher sensitivity than existing methods.

This study creates a single-cell and single-nucleus transcriptomic atlas of human skeletal muscle ageing, revealing mechanisms in muscle stem cells, myofibers, and the microenvironment.