Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
Celso M. Teixeira‐Duarte, Wan Fu, Weizhong Zeng, Jianghuang Wang, Xinzhe Jiang, Ziye Zhao, Qing Zhong, Youxing Jiang
This study identifies the molecular mechanism of Necrocide 1 activation of human TRPM4 and explains its species-specific selectivity using cryo-EM, electrophysiology, and cell death assays.
Nature Communications · Jun 24, 2026Peer-reviewedBiophysics