BiophysicsNature CommunicationsPeer-reviewed
Structural mechanism of Necrocide 1 activation of human TRPM4 that triggers necrosis by sodium overload
Celso M. Teixeira‐Duarte, Wan Fu, Weizhong Zeng…·Youxing Jiang
This study identifies the molecular mechanism of Necrocide 1 activation of human TRPM4 and explains its species-specific selectivity using cryo-EM, electrophysiology, and cell death assays.
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