PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current
Kirin D. Gada, Jordie M. Kamuene, Ana Santa‐Cruz, Ziyue Meng, Jenna G. Connolly, Florence Ng, Xinyi Ma, Aishwarya Chandrashekar, 徐瑜, Meng Cui, Leigh Daniel Plant
This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.
bioRxiv · Jul 3, 2026 · PreprintPhysiology