Meng Cui

This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.

The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.

This study identifies how PIP2 interacts with TMEM16A channels to activate them, revealing structural and functional insights for drug development.

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.