Leigh Daniel Plant

This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.

The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

The paper identifies PfApiAT2 as a proline transporter essential for Plasmodium falciparum oocyst development in mosquitoes, showing that its absence leads to defective sporozoite production and oocyst degeneration.

This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.

This study identifies how PIP2 interacts with TMEM16A channels to activate them, revealing structural and functional insights for drug development.

The paper shows SUMOylation of NaV1.2 channels increases backpropagation speed of action potentials in cortical neurons by enhancing persistent sodium current.