Author

Aishwarya Chandrashekar

Northeastern UniversityORCID 0009-0003-0633-1572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Leigh Daniel PlantiD· 3 shared Meng CuiiD· 3 shared Kirin D. GadaiD· 2 shared Takeharu KawanoiD· 2 shared Xinyi Ma· 2 shared Ana Santa Cruz· 1 shared Ana Santa‐CruziD· 1 shared Anne K. YauchiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersPhysiology

Leigh Daniel PlantORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 3, 2026

PIP2 stabilizes Nav1.5 gating and links receptor signaling to cardiac late sodium current

Kirin D. Gada, Jordie M. Kamuene, Ana Santa‐Cruz…·Leigh Daniel Plant

This study shows PIP2 stabilizes NaV1.5 gating and links Gq signaling to increased late sodium current, with implications for arrhythmias.

DOI 10.64898/2026.06.29.735321

humanelectronic health records

𝕏 PostBluesky

PhysiologybioRxivPreprintApr 25, 2025

Hypoxia Exacerbates Kir2.1 Channel Dysfunction in an Andersen-Tawil Syndrome Variant Through a SUMO-Dependent Mechanism

Aishwarya Chandrashekar, Yu Xu, Xinyi Ma…·Leigh Daniel Plant

This study shows hypoxia worsens Kir2.1 channel dysfunction in an Andersen-Tawil Syndrome variant through SUMOylation, and TAK-981 reverses this effect.

DOI 10.1101/2025.04.25.650734

humanelectrophysiology

𝕏 PostBluesky

BiophysicsbioRxivPreprintFeb 24, 2025

Orthosteric interactions with PIP2 activate TMEM16A channels

Jimin Xu, Ana Santa Cruz, Aishwarya Chandrashekar…·Leigh Daniel Plant

This study identifies how PIP2 interacts with TMEM16A channels to activate them, revealing structural and functional insights for drug development.

1 citation

electrophysiologymechanistic / dynamical model

𝕏 PostBluesky